HAPPEN improvement: Hydroxyapatite Emulsified Nanoparticles

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In the past we have talked about HAPPEN and cellulose in teeth remineralization ingredients.

We know that collagen makes up a large proportion of teeth.  Basically what happens is that amorphous calcium phosphate (ACP) mineralizes collagen fibers to form enamel.  Collagen can be used in this design but also I believe cellulose can work as well for a vegan alternative to collagen.  In this design we combine nano-hydroxyapatite (or microcrystalline hydroxyapatite, or ACP, or OCP or any other calcium phosphate or calcium phosphate forming compound) and combine it with collagen or cellulose or any other protein or fiber forming compound in a liquid slurry.  It then can be dried by any method including but not limited to lyophilization (freeze drying) or just standard drying with a fan.  

In our case our slurry will be formed with 12% hydrogen peroxide (H2O2) with nano hydroxyapatite and other molecules including calcium citrate as well as regenerated cellulose (made from cotton dissolved in phosphoric acid then diluted with water into the hot phosphoric acid to form microspheres then centrifuged and washed a few times to neutral pH.  Nano-cellulose or other similar fibers can also be used), and other minerals and amino acids including, magnesium glycinate, sodium citrate, zinc citrate, potassium gluconate, potassium iodide, selenium, aspartic acid, glutamic acid, possibly glycine, etc.  This will be made into a slurry and then dried at room temperature by a fan directed over it.

This will be dried and ground into a fine powder and this is enhanced nano hydroxyapatite peroxide.  This powder then will be added to saponins like ginseng extract and oils in the formulation along with more vitamins and amino acids and minerals and ground in a herb grinder to create HAPPEN which is emulsified nanoparticles of hydroxyapatite peroxide.  Other emulsifiers can be used, preferably of natural origin, but I found that phospholipids like those found in sunflower lecithin were bad and promoted infection and tooth root abscess in cracked teeth.

Citrate

https://www.pnas.org/content/107/52/22369

great article on remineralization

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.119.1783&rep=rep1&type=pdf

10% nano hap

https://www.obelis.net/news/nano-hydroxyapatite-is-it-safe/

dentine pulp graph

https://coggle.it/diagram/Wq9-j8GZixVNf-kF/t/3-dentine-pulp-complex

tubule size 1-5 um

http://www.dent.nu.ac.th/DFCT2017/fullpaper/JDAT%20DFCT10.pdf

amorphous calcium phosphate

https://oatao.univ-toulouse.fr/4680/1/Combes_4680.pdf

sodium citrate stabilizes h2o2

https://www.waterboards.ca.gov/losangeles/board_decisions/adopted_orders/WDR_Update/Sodiumcitrate,sodiummalonate,andsodiumphytate-OxidantActivators.pdf