7.13.2019

Tetracalcium Phosphosilicate: Next step in oral care

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TTCPS is Tetracalcium Phosphate that we know and love with some silicate to help nucleate remineralization of bone and/or teeth enamel or any other natural mineralization.

It can be used in any product from bone regrowth to artificial bones, to toothpaste and teeth powder, supplements, or anything else.  Bioglass patents require over 35% silicon dioxide in their formulation, so this TTCPS is less than 35% SiO2, preferably 14% or less of the final product.  Ideally the Silicon content would mimic bodily remineralization processes for bone and/or teeth such as saliva and the enamel surface.

I will guess that preferably around 3% silicon dioxide (so it would be Silicon Poor Tetracalcium Phosphosilicate) should be used and added the the tetracalcium phosphate precursor ingredients.  Calcium and phosphate should be in a 1.67 to 1 ratio or higher (or 1 mole CaOH, 1 mole Tricalcium phosphate) and silicon dioxide, or silicon dioxide containing ingredient, added in addition before forming the TTCPS by any method including high temperature melt, sol-gel, or any other method.  Can be used in conjunction with Dicalcium phophate or related mineral to produce hydroxyapatite or any other use.

More than the stoichiometric amounts of Ca or other alkalai/alkaline minerals can be used if desired to make an even more soluble and alkaline product.

This is how to make hydroxyapatite from tetracalcium phosphate and dicalcium phosphate (DCP):
Ca4 (PO4)2 O + Ca HPO4 => Ca5 (PO4)3 (OH) or  Ca10 (PO4)6 (OH)2

This is how TTCPS is formulated using 2 moles tetracalcium phosphate and 1 mole silicon dioxide:
2(Ca4 (PO4)2 O) + SiO2 => Ca8 (PO4)4 SiO4

Obviously the above shows that with full silication we won't be able to simply form hydroxyapatite (HA) by just combining DCP with TTCPS, so since we do want to form HA with addition of DCP, we want a silicon poor version.

Ca: 40
P: 31
O: 16
Si: 28

2 moles Ca(OH)2 which is 74g
 +
2 moles Ca3 (PO4)2 which is 310g
=
2 moles (Ca4 (PO4)2 O) which is 366g
+ H2O

then

2 moles (Ca4 (PO4)2 O) which is 366g
+
1 mole SiO2 which is 60g
=
1 mole  Ca8 (PO4)4 SiO4 which is 426g


TTCPS can also be peroxidized to form TTCPSP for even better adhesion to enamel as well.

Example full version:

74g CaOH
310g Tricalcium Phosphate
60g SiO2 or less

a 1:10 silicate poor version:

74g CaOH
310g Tricalcium Phosphate
6g SiO2

a 1:7 verison:

74g CaOH
310g Tricalcium Phosphate
8.57g SiO2

To this 3/4 cup distilled water is added and pressed in a pellet press or a little more water is added and made into a putty.  The putty is rolled flat on a cookie sheet and cookie cutter is used to make shapes.  These shapes are baked at 400f for 3 hours or until fully dry.

Then these discs can be treated with an HHO torch until molten or baked at sufficiently high temperature, roughly 1600c for several hours.

After this the new ingredient can be ground using a Micro-Mill and/or Ceramic mortar and pestle.  Any particle size can be used, the finer the better.  Nano is also possible but not ideal for dental use where swallowing or inhalation may happen.

Further this can be soaked in H2O2 preferably 35% or higher for several hours then air dried or dried using any method to form Tetracalcium Phospho-silicate peroxide which may have more active effects on teeth enamel.

Octacalcium phosphate:
https://www.sciencedirect.com/science/article/pii/0022024895009949

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